Biopharmaceuticals
 
Microbial Fermentation Broth Clarification
 

Microbial fermentation broth clarification may involve removal of host cells from the fermenter broth for extracellular proteins which can then be recovered from the filtrate.

In case of intracellular proteins, the cells are separated from the broth and lysed, and the lysate is clarified to remove cell debris and other suspended contaminants prior to downstream processing.

     

 

Microbial Fermentation Broth Clarification  
 
 
Application Area
Application
Filter
Key Product Features
Microbial Fermentation Broth Clarification Bioburden Reduction 0.2 µm gamma Sterilizable PES Membrane Inline Filter Type AseptiCap KL/KS- γ 25mm, 50mm  >  Absolute retention
 >  Low protein binding
 >  Very low hold up volume
 >  High flow rates
 >  100% Integrity tested
 >  pH Compatibility: 1-10
 >  Total traceability:
      Unique marking on each filter
 >  Individual certificate of quality
0.2 µm gamma Sterilizable PES Membrane Capsule Filter AseptiCap KS/KL- γ 1", 2", 5", 8" (with Prefilter)
0.2 µm gamma Sterilizable PES Membrane Large Capsule Filter AseptiCap KS- γ 10", 20", 30" (with Prefilter)
0.2 µm PES Membrane
Cartridge Filter
AseptiSure KS- 5", 10", 20", 30"
Pre-filtration Microglassfiber Membrane Capsule Filter ClariCap GS- 1", 2", 5", 8"  >  Very high retention efficiency     (99.999%)
 >  Heat stable construction
 >  Non media migrating
 >  Wide chemical compatibility
 >  Biologically inert
 >  High Throughputs
 >  pH Compatibility: 1-14
Microglassfiber Membrane Large Capsule Filter
ClariCap GS
- 10", 20", 30"
Microglassfiber Cartridge Filters
ClariSure GP- 5", 10", 20", 30"
Hydrophilic PES membrane capsule filter
ClariPro GK- 1", 2", 5", 8"
 > High Flow Rates
 > High Throughput
 > Very High Retention
 > Low Protein Binding
 > Compact Design
Hydrophilic PES Membrane Cartridge Filters with Microglassfiber upstream
ClariSure GK- 5", 10", 20", 30"
 
 
 



 
 
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  Biopharmaceuticals
- Recombinant Proteins
- Vaccines
- Plasma Fractions
- Monoclonal Antibodies

 Bioprocessing
  Cell Culture and Fermentation
  - Mammalian Cell Culture
  - Microbial Fermentation
  Harvesting and Clarification
  - Mammalian Cell Culture Clarification
  - Microbial Fermentation
Broth Clarification
  Downstream Processing
  Aseptic Fill and Finish

 
 
 
 
 
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